I drove from Missoula to Asheville. It was 2600 miles. It was long but not that bad.
Leaving La Paz was rough. Lots of stores were closed because of the holiday and finding food in the morning was challenging. Also, we ended up biking about 9 miles in a completely wrong direction, and so we started the day with 20 M’s before we went anywhere.
We also decided to not take Highway 1 out of La Paz. We thought a side road would have less traffic (which it did) and take us closer to the beach (which it did). What followed was possibly the 2 hardest days of biking I have ever done in my life.
Taking the 286 out of La Paz starts with a 15 mile up-hill (maybe 20?). Due to our misstep in the morning we did that in the hottest part of the day.
The giant uphill was followed by a downhill of about the same distance, most of which was on a single straight-away. It was wild to be coasting in the same direction at over 30 mph for half an hour. It was glorious.
Our route abandoned the paved road (which ends) and crossed some mountains on a dirt road. We did this in the late evening. It was rugged. By the time we were camping I remember any sort of movement was a serious challenge.